Ontology highlight
ABSTRACT:
SUBMITTER: Nolting S
PROVIDER: S-EPMC10146171 | biostudies-literature | 2023 Mar
REPOSITORIES: biostudies-literature
Nölting Sophia S März Camilla C Jacob Lucas L Persicke Marcus M Schneiker-Bekel Susanne S Kalinowski Jörn J
Microorganisms 20230327 4
The pseudo-tetrasaccharide acarbose, produced by <i>Actinoplanes</i> sp. SE50/110, is a α-glucosidase inhibitor used for treatment of type 2 diabetes patients. In industrial production of acarbose, by-products play a relevant role that complicates the purification of the product and reduce yields. Here, we report that the acarbose 4-α-glucanotransferase AcbQ modifies acarbose and the phosphorylated version acarbose 7-phosphate. Elongated acarviosyl metabolites (α-acarviosyl-(1,4)-maltooligosacch ...[more]