Ontology highlight
ABSTRACT:
SUBMITTER: Zhao Q
PROVIDER: S-EPMC5851932 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Zhao Qinqin Q Xie Huixin H Peng Yao Y Wang Xinran X Bai Linquan L
Synthetic and systems biotechnology 20171127 4
The α-glucosidase inhibitor acarbose is commercially produced by <i>Actinoplanes</i> sp. and used as a potent drug in the treatment of type-2 diabetes. In order to improve the yield of acarbose, an efficient genetic manipulation system for <i>Actinoplanes</i> sp. was established. The conjugation system between <i>E. coli</i> carrying ØC31-derived integrative plasmids and the mycelia of <i>Actinoplanes</i> sp. SE50/110 was optimized by adjusting the parameters of incubation time of mixed culture ...[more]