Ontology highlight
ABSTRACT:
SUBMITTER: Goldberg EL
PROVIDER: S-EPMC10150608 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Nature metabolism 20200120 1
Ketone bodies are essential alternative fuels that allow humans to survive periods of glucose scarcity induced by starvation and prolonged exercise. A widely used ketogenic diet (KD), which is extremely high in fat with very low carbohydrates, drives the host into using β-hydroxybutyrate for the production of ATP and lowers NLRP3-mediated inflammation. However, the extremely high fat composition of KD raises the question of how ketogenesis affects adipose tissue to control inflammation and energ ...[more]