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Ketogenesis activates metabolically protective γδ T cells in visceral adipose tissue

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Mus musculus

PROVIDER: GSE137077 | GEO | 2019/09/10

REPOSITORIES: GEO

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Ketogenesis activates metabolically protective γδ T cells in visceral adipose tissue.

Project description:Ketone bodies are essential alternative fuels that allow humans to survive periods of glucose scarcity induced by starvation and prolonged exercise. A widely used ketogenic diet (KD), which is extremely high in fat with very low carbohydrates, drives the host into using β-hydroxybutyrate for the production of ATP and lowers NLRP3-mediated inflammation. However, the extremely high fat composition of KD raises the question of how ketogenesis affects adipose tissue to control inflammation and energy homeostasis. Here, by using single-cell RNA sequencing of adipose-tissue-resident immune cells, we show that KD expands metabolically protective γδ T cells that restrain inflammation. Notably, long-term ad libitum KD feeding in mice causes obesity, impairs metabolic health and depletes the adipose-resident γδ T cells. In addition, mice lacking γδ T cells have impaired glucose homeostasis. Our results suggest that γδ T cells are mediators of protective immunometabolic responses that link fatty acid-driven fuel use to reduced adipose tissue inflammation.

| S-EPMC10150608 | biostudies-literature

Ketogenesis activates metabolically protective γδ T cells in visceral adipose tissue [scRNA-Seq]

Project description:Ketone bodies are essential alternative fuels that allow humans to survive periods of glucose scarcity induced by starvation and prolonged exercise. A widely used ketogenic diet (KD), that is extremely high in fat with very-low carbohydrates, drives the host into using β-hydroxybutyrate (BHB) for the production of ATP and lowers NLRP3-mediated inflammation. However, the extremely high fat composition of KD raises the question of how ketogenesis impacts adipose tissue to control inflammation and energy homeostasis. Using single-cell RNA sequencing of adipose tissue-resident immune cells, we identified that KD expands metabolically protective γδ T cells that restrain inflammation. However, a long-term KD caused obesity, impaired metabolic health and depleted the adipose resident γδ T cells. Moreover, mice lacking γδ T cells have impaired glucose homeostasis. We conclude that γδ T cells are mediators of protective immunometabolic responses that link fatty acid driven fuel utilization to reduced adipose tissue inflammation.

2019-09-10 | GSE137076 | GEO

Ketogenesis activates metabolically protective γδ T cells in visceral adipose tissue [bulk RNA-Seq]

Project description:Ketone bodies are essential alternative fuels that allow humans to survive periods of glucose scarcity induced by starvation and prolonged exercise. A widely used ketogenic diet (KD), that is extremely high in fat with very-low carbohydrates, drives the host into using β-hydroxybutyrate (BHB) for the production of ATP and lowers NLRP3-mediated inflammation. However, the extremely high fat composition of KD raises the question of how ketogenesis impacts adipose tissue to control inflammation and energy homeostasis. Using single-cell RNA sequencing of adipose tissue-resident immune cells, we identified that KD expands metabolically protective γδ T cells that restrain inflammation. However, a long-term KD caused obesity, impaired metabolic health and depleted the adipose resident γδ T cells. Moreover, mice lacking γδ T cells have impaired glucose homeostasis. We conclude that γδ T cells are mediators of protective immunometabolic responses that link fatty acid driven fuel utilization to reduced adipose tissue inflammation.

2019-09-10 | GSE137073 | GEO

Ketogenesis activates metabolically protective γδ T cells in visceral adipose tissue

Project description:Ketogenesis activates metabolically protective γδ T cells in visceral adipose tissue

| PRJNA564510 | ENA

Ketogenesis activates metabolically protective γδ T cells in visceral adipose tissue [scRNA-Seq]

Project description:Ketogenesis activates metabolically protective γδ T cells in visceral adipose tissue [scRNA-Seq]

| PRJNA564513 | ENA

Ketogenesis activates metabolically protective γδ T cells in visceral adipose tissue [bulk RNA-Seq]

Project description:Ketogenesis activates metabolically protective γδ T cells in visceral adipose tissue [bulk RNA-Seq]

| PRJNA564506 | ENA

DNA methylation from severely obese samples in liver, muscle, visceral adipose tissue and subcutaneous adipose samples

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2014-09-17 | E-GEOD-61454 | biostudies-arrayexpress

Adipose Precursor HO-1 determines healthy visceral adipose tissue expansion during obesity

Project description:This SuperSeries is composed of the SubSeries listed below.

2017-03-08 | GSE80148 | GEO

Tcf21 functions as a rate-limiting factor during visceral adipose tissue development

Project description:This SuperSeries is composed of the SubSeries listed below.

2023-02-28 | GSE196569 | GEO

DNA methylation from severely obese samples in liver, muscle, visceral adipose tissue and subcutaneous adipose samples

Project description:This SuperSeries is composed of the SubSeries listed below.

2014-09-17 | GSE61454 | GEO

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