Ontology highlight
ABSTRACT:
SUBMITTER: Hadjitheodorou A
PROVIDER: S-EPMC10150694 | biostudies-literature | 2023 Mar
REPOSITORIES: biostudies-literature
Hadjitheodorou Amalia A Bell George R R GRR Ellett Felix F Irimia Daniel D Tibshirani Robert R Collins Sean R SR Theriot Julie A JA
Cell systems 20230223 3
Maintaining persistent migration in complex environments is critical for neutrophils to reach infection sites. Neutrophils avoid getting trapped, even when obstacles split their front into multiple leading edges. How they re-establish polarity to move productively while incorporating receptor inputs under such conditions remains unclear. Here, we challenge chemotaxing HL60 neutrophil-like cells with symmetric bifurcating microfluidic channels to probe cell-intrinsic processes during the resoluti ...[more]