Ontology highlight
ABSTRACT:
SUBMITTER: Houk AR
PROVIDER: S-EPMC3308728 | biostudies-literature | 2012 Jan
REPOSITORIES: biostudies-literature
Cell 20120101 1-2
Little is known about how neutrophils and other cells establish a single zone of actin assembly during migration. A widespread assumption is that the leading edge prevents formation of additional fronts by generating long-range diffusible inhibitors or by sequestering essential polarity components. We use morphological perturbations, cell-severing experiments, and computational simulations to show that diffusion-based mechanisms are not sufficient for long-range inhibition by the pseudopod. Inst ...[more]