Ontology highlight
ABSTRACT:
SUBMITTER: Martell E
PROVIDER: S-EPMC10154337 | biostudies-literature | 2023 May
REPOSITORIES: biostudies-literature
Martell Emma E Kuzmychova Helgi H Kaul Esha E Senthil Harshal H Chowdhury Subir Roy SR Morrison Ludivine Coudière LC Fresnoza Agnes A Zagozewski Jamie J Venugopal Chitra C Anderson Chris M CM Singh Sheila K SK Banerji Versha V Werbowetski-Ogilvie Tamra E TE Sharif Tanveer T
Nature communications 20230502 1
Group 3 medulloblastoma (G3 MB) carries the worst prognosis of all MB subgroups. MYC oncoprotein is elevated in G3 MB tumors; however, the mechanisms that support MYC abundance remain unclear. Using metabolic and mechanistic profiling, we pinpoint a role for mitochondrial metabolism in regulating MYC. Complex-I inhibition decreases MYC abundance in G3 MB, attenuates the expression of MYC-downstream targets, induces differentiation, and prolongs male animal survival. Mechanistically, complex-I in ...[more]