Ontology highlight
ABSTRACT:
SUBMITTER: Izzo LT
PROVIDER: S-EPMC10156126 | biostudies-literature | 2023 May
REPOSITORIES: biostudies-literature
Science advances 20230503 18
The metabolite acetyl-CoA is necessary for both lipid synthesis in the cytosol and histone acetylation in the nucleus. The two canonical precursors to acetyl-CoA in the nuclear-cytoplasmic compartment are citrate and acetate, which are processed to acetyl-CoA by ATP-citrate lyase (ACLY) and acyl-CoA synthetase short-chain 2 (ACSS2), respectively. It is unclear whether other substantial routes to nuclear-cytosolic acetyl-CoA exist. To investigate this, we generated cancer cell lines lacking both ...[more]