Ontology highlight
ABSTRACT:
SUBMITTER: Kral J
PROVIDER: S-EPMC10157349 | biostudies-literature | 2023 Jun
REPOSITORIES: biostudies-literature
Kral Jan J Jelinkova Sandra S Zemankova Petra P Vocka Michal M Borecka Marianna M Cerna Leona L Cerna Marta M Dostalek Lukas L Duskova Petra P Foretova Lenka L Havranek Ondrej O Horackova Klara K Hovhannisyan Milena M Chvojka Stepan S Kalousova Marta M Kosarova Marcela M Koudova Monika M Krutilkova Vera V Machackova Eva E Nehasil Petr P Novotny Jan J Otahalova Barbora B Puchmajerova Alena A Safarikova Marketa M Slama Jiri J Stranecky Viktor V Subrt Ivan I Tavandzis Spiros S Zikan Michal M Zima Tomas T Soukupova Jana J Kleiblova Petra P Kleibl Zdenek Z Janatova Marketa M
Oncology letters 20230412 6
Endometrial cancer (EC) is the most common gynecological malignancy in developed countries. The present study aimed to determine the frequency of germline pathogenic variants (PV) in patients with EC. In this multicenter retrospective cohort study, germline genetic testing (GGT) was performed in 527 patients with EC using a next generation sequencing panel targeting 226 genes, including 5 Lynch syndrome (LS) and 14 hereditary breast and ovarian cancer (HBOC) predisposition genes, and 207 candida ...[more]