Ontology highlight
ABSTRACT:
SUBMITTER: Wang ZX
PROVIDER: S-EPMC101600 | biostudies-literature | 2000 Nov
REPOSITORIES: biostudies-literature
Wang Z X ZX Li S M SM Heide L L
Antimicrobial agents and chemotherapy 20001101 11
The biosynthetic gene cluster of the aminocoumarin antibiotic coumermycin A(1) was cloned by screening of a cosmid library of Streptomyces rishiriensis DSM 40489 with heterologous probes from a dTDP-glucose 4,6-dehydratase gene, involved in deoxysugar biosynthesis, and from the aminocoumarin resistance gyrase gene gyrB(r). Sequence analysis of a 30.8-kb region upstream of gyrB(r) revealed the presence of 28 complete open reading frames (ORFs). Fifteen of the identified ORFs showed, on average, 8 ...[more]