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Identification of the herboxidiene biosynthetic gene cluster in Streptomyces chromofuscus ATCC 49982.

ABSTRACT: The 53-kb biosynthetic gene cluster for the novel anticholesterol natural product herboxidiene was identified in Streptomyces chromofuscus ATCC 49982 by genome sequencing and gene inactivation. In addition to herboxidiene, a biosynthetic intermediate, 18-deoxy-herboxidiene, was also isolated from the fermentation broth of S. chromofuscus ATCC 49982 as a minor metabolite.

SUBMITTER: Shao L

PROVIDER: S-EPMC3298124 | biostudies-literature | 2012 Mar

REPOSITORIES: biostudies-literature

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Identification of the herboxidiene biosynthetic gene cluster in Streptomyces chromofuscus ATCC 49982.

Shao Lei L Zi Jiachen J Zeng Jia J Zhan Jixun J

Applied and environmental microbiology 20120113 6

The 53-kb biosynthetic gene cluster for the novel anticholesterol natural product herboxidiene was identified in Streptomyces chromofuscus ATCC 49982 by genome sequencing and gene inactivation. In addition to herboxidiene, a biosynthetic intermediate, 18-deoxy-herboxidiene, was also isolated from the fermentation broth of S. chromofuscus ATCC 49982 as a minor metabolite. ...[more]

PMID: 22247174

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