Cortical hierarchy disorganization in major depressive disorder and its association with suicidality.
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ABSTRACT: Objectives
To explore the suicide risk-specific disruption of cortical hierarchy in major depressive disorder (MDD) patients with diverse suicide risks.Methods
Ninety-two MDD patients with diverse suicide risks and 38 matched controls underwent resting-state functional MRI. Connectome gradient analysis and stepwise functional connectivity (SFC) analysis were used to characterize the suicide risk-specific alterations of cortical hierarchy in MDD patients.Results
Relative to controls, patients with suicide attempts (SA) had a prominent compression from the sensorimotor system; patients with suicide ideations (SI) had a prominent compression from the higher-level systems; non-suicide patients had a compression from both the sensorimotor system and higher-level systems, although it was less prominent relative to SA and SI patients. SFC analysis further validated this depolarization phenomenon.Conclusion
This study revealed MDD patients had suicide risk-specific disruptions of cortical hierarchy, which advance our understanding of the neuromechanisms of suicidality in MDD patients.
SUBMITTER: Shiwei L
PROVIDER: S-EPMC10165114 | biostudies-literature | 2023
REPOSITORIES: biostudies-literature
Publications
Cortical hierarchy disorganization in major depressive disorder and its association with suicidality.
Shiwei Lin L Xiaojing Zhang Z Yingli Zhang Z Shengli Chen C Xiaoshan Lin L Ziyun Xu X Gangqiang Hou H Yingwei Qiu Q
Frontiers in psychiatry 20230424
<h4>Objectives</h4>To explore the suicide risk-specific disruption of cortical hierarchy in major depressive disorder (MDD) patients with diverse suicide risks.<h4>Methods</h4>Ninety-two MDD patients with diverse suicide risks and 38 matched controls underwent resting-state functional MRI. Connectome gradient analysis and stepwise functional connectivity (SFC) analysis were used to characterize the suicide risk-specific alterations of cortical hierarchy in MDD patients.<h4>Results</h4>Relative t ...[more]
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