Dataset Information

High triglyceride glucose-body mass index correlates with prehypertension and hypertension in east Asian populations: A population-based retrospective study.

ABSTRACT:

Background

There is compelling evidence for an association between triglyceride glucose-body mass index (TyG-BMI) and cardiovascular disease (CVD). However, data on the relationship between TyG-BMI and prehypertension (pre-HTN) or hypertension (HTN) remains scant. The aim of this study was to characterize the association between TyG-BMI and pre-HTN or HTN risk, and to assess the ability of TyG-BMI in predicting pre-HTN and HTN in Chinese and Japanese populations.

Methods

A total of 214,493 participants were included in this study. The participants were divided into 5 groups based on quintiles of TyG-BMI index at baseline (Q1, Q2, Q3 Q4 and Q5). Logistic regression analysis was then employed to assess the relationship between TyG-BMI quintiles and pre-HTN or HTN. Results were presented as odds ratios (ORs) and 95% confidence intervals (CIs).

Results

Our restricted cubic spline analysis showed that TyG-BMI was linearly correlated with both pre-HTN and HTN. Multivariate logistic regression analysis indicated that TyG-BMI was independently correlated with pre-HTN [ORs and 95% CIs were 1.011 (1.011-1.012), 1.021 (1.02-1.023), 1.012 (1.012-1.012), respectively] and HTN [ORs and 95% CIs were 1.021 (1.02-1.021), 1.031 (1.028-1.033), 1.021 (1.02-1.021), respectively] in Chinese or Japanese individuals or both groups after adjusting for all variates. In addition, subgroup analyses showed that the relationship between TyG-BMI and pre-HTN or HTN was independent of age, sex, BMI, country, smoking and drinking status. Across all study populations, the areas under the TyG-BMI curve predicting pre-HTN and HTN were 0.667 and 0.762, respectively, resulting in cut-off values of 189.7 and 193.7, respectively.

Conclusion

Our analyses showed that TyG-BMI was independently correlated with both pre-HTN and HTN. Besides, TyG-BMI showed superior predictive power in predicting pre-HTN and HTN compared to TyG or BMI alone.

SUBMITTER: Chen L

PROVIDER: S-EPMC10166815 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

High triglyceride glucose-body mass index correlates with prehypertension and hypertension in east Asian populations: A population-based retrospective study.

Chen Lu L He Linfeng L Zheng Wenbin W Liu Qiuying Q Ren Yifan Y Kong Wen W Zeng Tianshu T

Frontiers in cardiovascular medicine 20230425

<h4>Background</h4>There is compelling evidence for an association between triglyceride glucose-body mass index (TyG-BMI) and cardiovascular disease (CVD). However, data on the relationship between TyG-BMI and prehypertension (pre-HTN) or hypertension (HTN) remains scant. The aim of this study was to characterize the association between TyG-BMI and pre-HTN or HTN risk, and to assess the ability of TyG-BMI in predicting pre-HTN and HTN in Chinese and Japanese populations.<h4>Methods</h4>A total o ...[more]

PMID: 37180805

Similar Datasets

Project description:BackgroundCardiovascular disease (CVD) is a leading cause of global mortality, with increasing prevalence and impact, especially in the elderly and developing countries. Insulin resistance (IR) plays a significant role in CVD progression, and the triglyceride glucose-body mass index (TyG-BMI) index, combining fasting glucose and triglycerides, offers a simple, cost-effective method for assessing IR. However, its prognostic value in CVD populations remains underexplored. This study aims to investigate the relationship between TyG-BMI and mortality in CVD patients.MethodsData from the National Health and Nutrition Examination Survey (NHANES) (1999-2018) combined with the linked National Death Index were analyzed. The CVD population was split into two groups (Q1 and Q2) based on the median TyG-BMI. The primary outcomes were all-cause mortality and cause-specific mortality.ResultsThe study ultimately included 2,576 participants, of which 56% were male. The median age of the participants was 69 years, and the median TyG-BMI was 256.59. After adjusting for potential confounders, a negative relationship was found between TyG-BMI and all-cause mortality in populations with CVD, coronary heart disease (CHD), congestive heart failure (CHF), and heart attack. The hazard ratios (HR) and 95% confidence intervals (CI) were 0.73 (0.64, 0.85), 0.67 (0.53, 0.84), 0.69 (0.54, 0.88), and 0.73 (0.59, 0.91), respectively. At the same time, a notable inverse relationship was noted between the TyG-BMI and non-CVD mortality in the CVD and CHD population, with HR and 95% CI of 0.70 (0.58, 0.84) and 0.61 (0.45, 0.82), respectively. In this study, there was no observed noteworthy relationship between TyG-BMI and CVD mortality. Furthermore, sensitivity analysis yielded similar results.ConclusionAmong populations with CVD in the United States, a heightened TyG-BMI was notably correlated with a decreased likelihood of mortality. This index can effectively classify the risk levels of CVD patients and may serve as a valuable prognostic marker.

Dataset Information

High triglyceride glucose-body mass index correlates with prehypertension and hypertension in east Asian populations: A population-based retrospective study.

Background

Methods

Results

Conclusion

Publications

High triglyceride glucose-body mass index correlates with prehypertension and hypertension in east Asian populations: A population-based retrospective study.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets