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ABSTRACT:
SUBMITTER: Kattula B
PROVIDER: S-EPMC10171901 | biostudies-literature | 2023 Jul
REPOSITORIES: biostudies-literature
Kattula Bhavita B Reddi Bharati B Jangam Aruna A Naik Lekhika L Adimoolam Bala Manikanta BM Vavilapalli Suresh S Are Sayanna S Thota Jagadeshwar Reddy JR Jadav Surender Singh SS Arifuddin Mohammed M Addlagatta Anthony A
International journal of biological macromolecules 20230511 Pt 2
Evolution of new variants of SARS-CoV-2 warrant the need for the continued efforts in identifying target-oriented new drugs. Dual targeting agents against M<sup>Pro</sup> and PL<sup>Pro</sup> not only overcome the incomplete efficacy but also the drug resistance, which is common problem. Since both these are cysteine proteases, we designed 2-chloroquinoline based molecules with additional imine moiety in the middle as possible nucleophilic warheads. In the first round of design and synthesis, th ...[more]