Ontology highlight
ABSTRACT:
SUBMITTER: Taylor AJ
PROVIDER: S-EPMC11318101 | biostudies-literature | 2024 Aug
REPOSITORIES: biostudies-literature
Taylor Ashley J AJ Amporndanai Kangsa K Rietz Tyson A TA Zhao Bin B Thiruvaipati Anusha A Wei Qiangqiang Q South Taylor M TM Crow Mackenzie M MM Apakama Chideraa C Sensintaffar John L JL Phan Jason J Lee Taekyu T Fesik Stephen W SW
ACS medicinal chemistry letters 20240723 8
Coronaviruses have been responsible for numerous viral outbreaks in the past two decades due to the high transmission rate of this family of viruses. The deadliest outbreak is the recent Covid-19 pandemic, which resulted in over 7 million deaths worldwide. SARS-CoV-2 papain-like protease (PL<sup>Pro</sup>) plays a key role in both viral replication and host immune suppression and is highly conserved across the coronavirus family, making it an ideal drug target. Herein we describe a fragment-base ...[more]