Ontology highlight
ABSTRACT:
SUBMITTER: Hiroki H
PROVIDER: S-EPMC10172294 | biostudies-literature | 2023 May
REPOSITORIES: biostudies-literature
Hiroki Haruka H Ishii Yuko Y Piao Jinhua J Namikawa Yui Y Masutani Mitsuko M Honda Hiroaki H Akahane Koshi K Inukai Takeshi T Morio Tomohiro T Takagi Masatoshi M
Scientific reports 20230510 1
BCR/ABL1 causes dysregulated cell proliferation and is responsible for chronic myelogenous leukemia (CML) and Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph1-ALL). In addition to the deregulatory effects of its kinase activity on cell proliferation, BCR/ABL1 induces genomic instability by downregulating BRCA1. PARP inhibitors (PARPi) effectively induce cell death in BRCA-defective cells. Therefore, PARPi are expected to inhibit growth of CML and Ph1-ALL cells showing downregul ...[more]