Ontology highlight
ABSTRACT:
SUBMITTER: Yang ES
PROVIDER: S-EPMC3771348 | biostudies-literature | 2012 Nov
REPOSITORIES: biostudies-literature
Yang Eddy S ES Nowsheen Somaira S Rahman Mohammad A MA Cook Rebecca S RS Xia Fen F
Cancer research 20120907 21
PARP inhibitors have gained recent attention due to their highly selective killing of BRCA1/2-mutated and DNA double-strand break (DSB) repair-deficient tumors. Unfortunately, the majority of sporadic breast cancers carry wild-type BRCA1/2 and are proficient in DSB repair. We and others have shown that BRCA1 is a nuclear/cytoplasm shuttling protein that is transiently exported from the nucleus to the cytosol upon various stimuli. Thus, we hypothesized that depletion of nuclear BRCA1 would compro ...[more]