Ontology highlight
ABSTRACT:
SUBMITTER: Melby JA
PROVIDER: S-EPMC10175728 | biostudies-literature | 2023 May
REPOSITORIES: biostudies-literature
Melby Jake A JA Brown Kyle A KA Gregorich Zachery R ZR Roberts David S DS Chapman Emily A EA Ehlers Lauren E LE Gao Zhan Z Larson Eli J EJ Jin Yutong Y Lopez Justin R JR Hartung Jared J Zhu Yanlong Y McIlwain Sean J SJ Wang Daojing D Guo Wei W Diffee Gary M GM Ge Ying Y
Proceedings of the National Academy of Sciences of the United States of America 20230501 19
Single-cell proteomics has emerged as a powerful method to characterize cellular phenotypic heterogeneity and the cell-specific functional networks underlying biological processes. However, significant challenges remain in single-cell proteomics for the analysis of proteoforms arising from genetic mutations, alternative splicing, and post-translational modifications. Herein, we have developed a highly sensitive functionally integrated top-down proteomics method for the comprehensive analysis of ...[more]