Ontology highlight
ABSTRACT:
SUBMITTER: Kubo S
PROVIDER: S-EPMC10181974 | biostudies-literature | 2023 Jun
REPOSITORIES: biostudies-literature
Kubo Shutaro S Miyakawa Momoko M Tada Asuka A Oda Hirotsugu H Motobayashi Hideki H Iwabuchi Sadahiro S Tamura Shinobu S Tanaka Miyuki M Hashimoto Shinichi S
Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine 20220826 3
Plasmacytoid dendritic cells (pDCs) recognise viral single-stranded RNA (ssRNA) or CpG DNA via Toll-like receptor (TLR)-7 and TLR9, and produce interferon (IFN)-α. Activated pDCs upregulate human leukocyte antigen (HLA)-DR and CD86 expression levels. Ingestion of bovine lactoferrin (LF) activates pDCs, but little is known about its effects. In this study, the effects of LF and its pepsin hydrolysate (LFH) on the production of IFN-α from peripheral blood mononuclear cells (PBMCs) and pDCs were ex ...[more]