Ontology highlight
ABSTRACT:
SUBMITTER: Wimmers F
PROVIDER: S-EPMC6102223 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Wimmers Florian F Subedi Nikita N van Buuringen Nicole N Heister Daan D Vivié Judith J Beeren-Reinieren Inge I Woestenenk Rob R Dolstra Harry H Piruska Aigars A Jacobs Joannes F M JFM van Oudenaarden Alexander A Figdor Carl G CG Huck Wilhelm T S WTS de Vries I Jolanda M IJM Tel Jurjen J
Nature communications 20180820 1
Type I interferon (IFN) is a key driver of immunity to infections and cancer. Plasmacytoid dendritic cells (pDCs) are uniquely equipped to produce large quantities of type I IFN but the mechanisms that control this process are poorly understood. Here we report on a droplet-based microfluidic platform to investigate type I IFN production in human pDCs at the single-cell level. We show that type I IFN but not TNFα production is limited to a small subpopulation of individually stimulated pDCs and c ...[more]