Ontology highlight
ABSTRACT:
SUBMITTER: Bourquard T
PROVIDER: S-EPMC10183026 | biostudies-literature | 2023 May
REPOSITORIES: biostudies-literature
Bourquard Thomas T Lee Kwanghyuk K Al-Ramahi Ismael I Pham Minh M Shapiro Dillon D Lagisetty Yashwanth Y Soleimani Shirin S Mota Samantha S Wilhelm Kevin K Samieinasab Maryam M Kim Young Won YW Huh Eunna E Asmussen Jennifer J Katsonis Panagiotis P Botas Juan J Lichtarge Olivier O
Nature communications 20230513 1
The incidence of Alzheimer's Disease in females is almost double that of males. To search for sex-specific gene associations, we build a machine learning approach focused on functionally impactful coding variants. This method can detect differences between sequenced cases and controls in small cohorts. In the Alzheimer's Disease Sequencing Project with mixed sexes, this approach identified genes enriched for immune response pathways. After sex-separation, genes become specifically enriched for s ...[more]