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A sustainable metal and base-free direct amidation of esters using water as a green solvent.

ABSTRACT: Herein, we report a simple and efficient synthetic approach for direct amidation of esters via C(acyl)-O bond cleavage without any additional reagents or catalysts, using only water as a green solvent. Subsequently, the reaction byproduct is recovered and utilized for the next phase of ester synthesis. This method emphasized metal-free, additive-free, and base-free characteristics making it a new, sustainable, and eco-friendly way to realize direct amide bond formation. In addition, the synthesis of the drug molecule diethyltoluamide and the Gram-scale synthesis of a representative amide are demonstrated.

SUBMITTER: Rajendran N

PROVIDER: S-EPMC10186333 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature

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A sustainable metal and base-free direct amidation of esters using water as a green solvent.

Rajendran Nanthini N Kamaraj Kiruthigadevi K Janakiraman Saranya S Saral Mary M Dixneuf Pierre H PH Bheeter Charles Beromeo CB

RSC advances 20230516 22

Herein, we report a simple and efficient synthetic approach for direct amidation of esters <i>via</i> C(acyl)-O bond cleavage without any additional reagents or catalysts, using only water as a green solvent. Subsequently, the reaction byproduct is recovered and utilized for the next phase of ester synthesis. This method emphasized metal-free, additive-free, and base-free characteristics making it a new, sustainable, and eco-friendly way to realize direct amide bond formation. In addition, the s ...[more]

PMID: 37200700

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