Ontology highlight
ABSTRACT:
SUBMITTER: Pan Y
PROVIDER: S-EPMC10194703 | biostudies-literature | 2023 Apr
REPOSITORIES: biostudies-literature
Pan Yangang Y Pohjolainen Emmi E Schmidpeter Philipp A M PAM Vaiana Andrea C AC Nimigean Crina M CM Grubmüller Helmut H Scheuring Simon S
Nature structural & molecular biology 20230327 4
Cyclic nucleotide-gated ion channels are crucial in many physiological processes such as vision and pacemaking in the heart. SthK is a prokaryotic homolog with high sequence and structure similarities to hyperpolarization-activated and cyclic nucleotide-modulated and cyclic nucleotide-gated channels, especially at the level of the cyclic nucleotide binding domains (CNBDs). Functional measurements showed that cyclic adenosine monophosphate (cAMP) is a channel activator while cyclic guanosine mono ...[more]