Unknown

Dataset Information

0

Drug-coated balloon-based versus drug-eluting stent-only revascularization in patients with diabetes and multivessel coronary artery disease.


ABSTRACT:

Background

Data on drug-coated balloon (DCB) treatment in the context of diabetes mellitus (DM) and multivessel coronary artery disease (CAD) are limited. We aimed to investigate the clinical impact of DCB-based revascularization on percutaneous coronary intervention (PCI) in patients with DM and multivessel CAD.

Methods

A total of 254 patients with multivessel disease (104 patients with DM) successfully treated with DCB alone or combined with drug-eluting stent (DES) were retrospectively enrolled (DCB-based group) and compared with 254 propensity-matched patients treated with second-generation DES from the PTRG-DES registry (n = 13,160 patients) (DES-only group). Major adverse cardiovascular events (MACE) comprised cardiac death, myocardial infarction, stroke, stent or target lesion thrombosis, target vessel revascularization, and major bleeding at 2 years.

Results

The DCB-based group was associated with a reduced risk of MACE in patients with DM (hazard ratio [HR] 0.19, 95% confidence interval [CI] 0.05-0.68, p = 0.003], but not in those without DM (HR 0.52, 95% CI 0.20-1.38, p = 0.167) at the 2-year follow-up. In patients with DM, the risk of cardiac death was lower in the DCB-based group than the DES-only group, but not in those without DM. In both patients with or without DM, the burdens of DES and small DES (less than 2.5 mm) used were lower in the DCB-based group than in the DES-only group.

Conclusions

In multivessel CAD, the clinical benefit of a DCB-based revascularization strategy appears to be more evident in patients with DM than in those without DM after 2 years of follow-up. (Impact of Drug-Coated Balloon Treatment in De Novo Coronary Lesion; NCT04619277).

SUBMITTER: Her AY 

PROVIDER: S-EPMC10199476 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature

altmetric image

Publications

Drug-coated balloon-based versus drug-eluting stent-only revascularization in patients with diabetes and multivessel coronary artery disease.

Her Ae-Young AY   Shin Eun-Seok ES   Kim Sunwon S   Kim Bitna B   Kim Tae-Hyun TH   Sohn Chang-Bae CB   Choi Byung Joo BJ   Park Yongwhi Y   Cho Jung Rae JR   Jeong Young-Hoon YH  

Cardiovascular diabetology 20230520 1


<h4>Background</h4>Data on drug-coated balloon (DCB) treatment in the context of diabetes mellitus (DM) and multivessel coronary artery disease (CAD) are limited. We aimed to investigate the clinical impact of DCB-based revascularization on percutaneous coronary intervention (PCI) in patients with DM and multivessel CAD.<h4>Methods</h4>A total of 254 patients with multivessel disease (104 patients with DM) successfully treated with DCB alone or combined with drug-eluting stent (DES) were retrosp  ...[more]

Similar Datasets

| S-EPMC10721670 | biostudies-literature
| S-EPMC11387717 | biostudies-literature
| S-EPMC5834842 | biostudies-literature
| S-EPMC6571399 | biostudies-literature
| S-EPMC4944845 | biostudies-literature
| S-EPMC5405921 | biostudies-literature
| S-EPMC11413635 | biostudies-literature
| S-EPMC10716315 | biostudies-literature
| S-EPMC9623093 | biostudies-literature