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An open pore structure of the Orai channel, finally.

ABSTRACT: Store-operated Orai channels are a primary mechanism for mobilizing Ca²⁺ signals in both non-excitable cells and excitable cells. The structure of the open channel, vital for understanding the mechanism of channel opening, is incompletely understood. We highlight a new study that unveils the structure of a constitutively active Orai mutant and takes us closer towards understanding the molecular basis of Orai channel activation.

SUBMITTER: Prakriya M

PROVIDER: S-EPMC10202095 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature

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An open pore structure of the Orai channel, finally.

Prakriya Murali M Yeung Priscilla See-Wai PS Yamashita Megumi M

Cell calcium 20210202

Store-operated Orai channels are a primary mechanism for mobilizing Ca<sup>2+</sup> signals in both non-excitable cells and excitable cells. The structure of the open channel, vital for understanding the mechanism of channel opening, is incompletely understood. We highlight a new study that unveils the structure of a constitutively active Orai mutant and takes us closer towards understanding the molecular basis of Orai channel activation. ...[more]

PMID: 33581587

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