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Replication of Novel Zoonotic-Like Influenza A(H3N8) Virus in Ex Vivo Human Bronchus and Lung.

ABSTRACT: Human infection with avian influenza A(H3N8) virus is uncommon but can lead to acute respiratory distress syndrome. In explant cultures of the human bronchus and lung, novel H3N8 virus showed limited replication efficiency in bronchial and lung tissue but had a higher replication than avian H3N8 virus in lung tissue.

SUBMITTER: Hui KPY

PROVIDER: S-EPMC10202868 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature

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Replication of Novel Zoonotic-Like Influenza A(H3N8) Virus in Ex Vivo Human Bronchus and Lung.

Hui Kenrie P Y KPY Ho John C W JCW Ng Ka-Chun KC Cheng Samuel M S SMS Sit Ko-Yung KY Au Timmy W K TWK Poon Leo L M LLM Nicholls John M JM Peiris Malik M Chan Michael C W MCW

Emerging infectious diseases 20230424 6

Human infection with avian influenza A(H3N8) virus is uncommon but can lead to acute respiratory distress syndrome. In explant cultures of the human bronchus and lung, novel H3N8 virus showed limited replication efficiency in bronchial and lung tissue but had a higher replication than avian H3N8 virus in lung tissue. ...[more]

PMID: 37095078

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