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The role of LIN28B in tumor progression and metastasis in solid tumor entities.

ABSTRACT: LIN28B is an RNA-binding protein that targets a broad range of microRNAs and modulates their maturation and activity. Under normal conditions, LIN28B is exclusively expressed in embryogenic stem cells, blocking differentiation and promoting proliferation. In addition, it can play a role in epithelial-to-mesenchymal transition by repressing the biogenesis of let-7 microRNAs. In malignancies, LIN28B is frequently overexpressed, which is associated with increased tumor aggressiveness and metastatic properties. In this review, we discuss the molecular mechanisms of LIN28B in promoting tumor progression and metastasis in solid tumor entities and its potential use as a clinical therapeutic target and biomarker.

SUBMITTER: Gewalt T

PROVIDER: S-EPMC10208000 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature

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The role of LIN28B in tumor progression and metastasis in solid tumor entities.

Gewalt Tabea T Noh Ka-Won KW Meder Lydia L

Oncology research 20230410 2

LIN28B is an RNA-binding protein that targets a broad range of microRNAs and modulates their maturation and activity. Under normal conditions, LIN28B is exclusively expressed in embryogenic stem cells, blocking differentiation and promoting proliferation. In addition, it can play a role in epithelial-to-mesenchymal transition by repressing the biogenesis of let-7 microRNAs. In malignancies, LIN28B is frequently overexpressed, which is associated with increased tumor aggressiveness and metastatic ...[more]

PMID: 37304235

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LIN28B promotes colon cancer progression and metastasis.

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| S-EPMC3117110 | biostudies-literature

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| S-EPMC7441421 | biostudies-literature

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LIN28B promotes neuroblastoma metastasis and regulates PDZ binding kinase.

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| S-EPMC4558200 | biostudies-literature

Microbiota-Derived Metabolites in Tumor Progression and Metastasis.

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| S-EPMC7460823 | biostudies-literature

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