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Microbiota-Derived Metabolites in Tumor Progression and Metastasis.


ABSTRACT: Microbial communities and human cells, through a dynamic crosstalk, maintain a mutualistic relationship that contributes to the maintenance of cellular metabolism and of the immune and neuronal systems. This dialogue normally occurs through the production and regulation of hormonal intermediates, metabolites, secondary metabolites, proteins, and toxins. When the balance between host and microbiota is compromised, the dynamics of this relationship change, creating favorable conditions for the development of diseases, including cancers. Microbiome metabolites can be important modulators of the tumor microenvironment contributing to regulate inflammation, proliferation, and cell death, in either a positive or negative way. Recent studies also highlight the involvement of microbiota metabolites in inducing epithelial-mesenchymal transition, thus favoring the setup of the metastatic niche. An investigation of microbe-derived metabolites in "liquid" human samples, such as plasma, serum, and urine, provide further information to clarify the relationship between host and microbiota.

SUBMITTER: Rossi T 

PROVIDER: S-EPMC7460823 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature

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Microbiota-Derived Metabolites in Tumor Progression and Metastasis.

Rossi Tania T   Vergara Daniele D   Fanini Francesca F   Maffia Michele M   Bravaccini Sara S   Pirini Francesca F  

International journal of molecular sciences 20200812 16


Microbial communities and human cells, through a dynamic crosstalk, maintain a mutualistic relationship that contributes to the maintenance of cellular metabolism and of the immune and neuronal systems. This dialogue normally occurs through the production and regulation of hormonal intermediates, metabolites, secondary metabolites, proteins, and toxins. When the balance between host and microbiota is compromised, the dynamics of this relationship change, creating favorable conditions for the dev  ...[more]

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