Ontology highlight
ABSTRACT:
SUBMITTER: Ma MS
PROVIDER: S-EPMC10210164 | biostudies-literature | 2023
REPOSITORIES: biostudies-literature
Ma Marshall S MS Sundaram Subramanian S Lou Lihua L Agarwal Arvind A Chen Christopher S CS Bifano Thomas G TG
Frontiers in bioengineering and biotechnology 20230511
<b>Introduction:</b> Three dimensional engineered cardiac tissues (3D ECTs) have become indispensable as <i>in vitro</i> models to assess drug cardiotoxicity, a leading cause of failure in pharmaceutical development. A current bottleneck is the relatively low throughput of assays that measure spontaneous contractile forces exerted by millimeter-scale ECTs typically recorded through precise optical measurement of deflection of the polymer scaffolds that support them. The required resolution and s ...[more]