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Research progress of interleukin-15 in cancer immunotherapy.


ABSTRACT: Interleukin-15 (IL-15) is a cytokine that belongs to the interleukin-2 (IL-2) family and is essential for the development, proliferation, and activation of immune cells, including natural killer (NK) cells, T cells and B cells. Recent studies have revealed that interleukin-15 also plays a critical role in cancer immunotherapy. Interleukin-15 agonist molecules have shown that interleukin-15 agonists are effective in inhibiting tumor growth and preventing metastasis, and some are undergoing clinical trials. In this review, we will summarize the recent progress in interleukin-15 research over the past 5 years, highlighting its potential applications in cancer immunotherapy and the progress of interleukin-15 agonist development.

SUBMITTER: Cai M 

PROVIDER: S-EPMC10213988 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature

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Research progress of interleukin-15 in cancer immunotherapy.

Cai Menghan M   Huang Xuan X   Huang Xiting X   Ju Dianwen D   Zhu Yi Zhun YZ   Ye Li L  

Frontiers in pharmacology 20230512


Interleukin-15 (IL-15) is a cytokine that belongs to the interleukin-2 (IL-2) family and is essential for the development, proliferation, and activation of immune cells, including natural killer (NK) cells, T cells and B cells. Recent studies have revealed that interleukin-15 also plays a critical role in cancer immunotherapy. Interleukin-15 agonist molecules have shown that interleukin-15 agonists are effective in inhibiting tumor growth and preventing metastasis, and some are undergoing clinic  ...[more]

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