Ontology highlight
ABSTRACT:
SUBMITTER: Liang X
PROVIDER: S-EPMC5239545 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
Liang Xiao X Luo Min M Wei Xia-Wei XW Ma Cui-Cui CC Yang Yu-Han YH Shao Bin B Liu Yan-Tong YT Liu Ting T Ren Jun J Liu Li L He Zhi-Yao ZY Wei Yu-Quan YQ
Oncotarget 20160801 32
Interleukin-15 has been implicated as a promising cytokine for cancer immunotherapy, while folate receptor α (FRα) has been shown to be a potentially useful target for colon cancer therapy. Herein, we developed F-PLP/pIL15, a FRα-targeted lipoplex loading recombinant interleukin-15 plasmid (pIL15) and studied its antitumor effects in vivo using a CT26 colon cancer mouse model. Compared with control (normal saline) treatment, F-PLP/pIL15 significantly suppressed tumor growth in regard to tumor we ...[more]