Ontology highlight
ABSTRACT:
SUBMITTER: Furrow E
PROVIDER: S-EPMC10218235 | biostudies-literature | 2023 Apr
REPOSITORIES: biostudies-literature
Furrow Eva E Tate Nicole N Minor Katie K Martinson Shannon S Larrabee Shannon S Anttila Marjukka M Sleeper Meg M Henthorn Paula P
Genes 20230427 5
Sudden cardiac death in the young (SCDY) is a devastating event that often has an underlying genetic basis. Manchester Terrier dogs offer a naturally occurring model of SCDY, with sudden death of puppies as the manifestation of an inherited dilated cardiomyopathy (DCM). We performed a genome-wide association study for SCDY/DCM in Manchester Terrier dogs and identified a susceptibility locus harboring the cardiac ATP-sensitive potassium channel gene <i>ABCC9</i>. Sanger sequencing revealed an <i> ...[more]