Ontology highlight
ABSTRACT:
SUBMITTER: Witte MB
PROVIDER: S-EPMC10219437 | biostudies-literature | 2023 May
REPOSITORIES: biostudies-literature
Witte Maria B MB Saupe Johannes J Reiner Johannes J Bannert Karen K Schafmayer Clemens C Lamprecht Georg G Berlin Peggy P
Journal of clinical medicine 20230522 10
Ileocecal resection (ICR) is frequently performed in Crohn's disease (CD). <i>NOD2</i> mutations are risk factors for CD. <i>Nod2</i> knockout (ko) mice show impaired anastomotic healing after extended ICR. We further investigated the role of NOD2 after limited ICR. C57B16/J (wt) and <i>Nod2</i> ko littermates underwent limited ICR including 1-2 cm terminal ileum and were randomly assigned to vehicle or MDP treatment. Bursting pressure was measured on POD 5, and the anastomosis was analyzed for ...[more]