Ontology highlight
ABSTRACT:
SUBMITTER: Doan PTB
PROVIDER: S-EPMC10223333 | biostudies-literature | 2023 May
REPOSITORIES: biostudies-literature
Doan Phuong Thi Bich PTB Nio Kouki K Shimakami Tetsuro T Kuroki Kazuyuki K Li Ying-Yi YY Sugimoto Saiho S Takayama Hideo H Okada Hikari H Kaneko Shuichi S Honda Masao M Yamashita Taro T
Viruses 20230516 5
Infection with hepatitis B virus (HBV) cannot be cured completely because of the persistence of covalently closed circular DNA (cccDNA). We previously found that the host gene dedicator of cytokinesis 11 (DOCK11) was required for HBV persistence. In this study, we further investigated the mechanism that links DOCK11 to other host genes in the regulation of cccDNA transcription. cccDNA levels were determined by quantitative real-time polymerase chain reaction (qPCR) and fluorescence in situ hybri ...[more]