Ontology highlight
ABSTRACT:
SUBMITTER: Gupta S
PROVIDER: S-EPMC10240201 | biostudies-literature | 2023 Jun
REPOSITORIES: biostudies-literature
Gupta Shamba S Bhagavathula Madhuri M Sharma Vartika V Sharma Nishant N Sharma Nevadita N Biswas Ashis A Palacios Ainhoa A Salgueiro Vivian V Lavín Jose L JL Dogra Navneet N Salgame Padmini P Prados-Rosales Rafael R Rodríguez G Marcela GM
EMBO reports 20230420 6
Mycobacterium tuberculosis (Mtb) secretes extracellular vesicles (EVs) containing a variety of proteins, lipoproteins, and lipoglycans. While emerging evidence suggests that EVs contribute to tuberculosis pathogenesis, the factors and molecular mechanisms involved in mycobacterial EV production have not been identified. In this study, we use a genetic approach to identify Mtb proteins that mediate vesicle release in response to iron limitation and antibiotic exposure. We uncover a critical role ...[more]