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Nano drug-delivery systems for management of AIDS: liposomes, dendrimers, gold and silver nanoparticles.

ABSTRACT: AIDS causes increasing mortality every year. With advancements in nanomedicine, different nanomaterials (NMs) have been applied to treat AIDS and overcome its limitations. Among different NMs, nanoparticles (NPs) can act as nanocarriers due to their enhanced solubility, sustained release, targeting abilities and facilitation of drug-dose reductions. This review discusses recent advancements in therapeutics for AIDS/HIV using various NMs, mainly focused on three classifications: polymeric, liposomal and inorganic NMs. Polymeric dendrimers, polyethylenimine-NPs, poly(lactic-co-glycolic acid)-NPs, chitosan and the use of liposomal-based delivery systems and inorganic NPs, including gold and silver NPs, are explored. Recent advances, current challenges and future perspectives on the use of these NMs for better management of HIV/AIDS are also discussed.

SUBMITTER: Asl FD

PROVIDER: S-EPMC10242436 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature

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Nano drug-delivery systems for management of AIDS: liposomes, dendrimers, gold and silver nanoparticles.

Asl Fateme Davarani FD Mousazadeh Marziyeh M Taji Shirinsadat S Bahmani Abbas A Khashayar Patricia P Azimzadeh Mostafa M Mostafavi Ebrahim E

Nanomedicine (London, England) 20230201 3

AIDS causes increasing mortality every year. With advancements in nanomedicine, different nanomaterials (NMs) have been applied to treat AIDS and overcome its limitations. Among different NMs, nanoparticles (NPs) can act as nanocarriers due to their enhanced solubility, sustained release, targeting abilities and facilitation of drug-dose reductions. This review discusses recent advancements in therapeutics for AIDS/HIV using various NMs, mainly focused on three classifications: polymeric, liposo ...[more]

PMID: 37125616

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