Reduced acetylation of TFAM promotes bioenergetic dysfunction in the failing heart.
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ABSTRACT:
SUBMITTER: Zhang M
PROVIDER: S-EPMC10250906 | biostudies-literature | 2023 Jun
REPOSITORIES: biostudies-literature
Publications
Reduced acetylation of TFAM promotes bioenergetic dysfunction in the failing heart.
Zhang Manling M Feng Ning N Peng Zishan Z Thapa Dharendra D Stoner Michael W MW Manning Janet R JR McTiernan Charles F CF Yang Xue X Jurczak Michael J MJ Guimaraes Danielle D Rao Krithika K Shiva Sruti S Kaufman Brett A BA Sack Michael N MN Scott Iain I
iScience 20230523 6
General control of amino acid synthesis 5-like 1 (GCN5L1) was previously identified as a key regulator of protein lysine acetylation in mitochondria. Subsequent studies demonstrated that GCN5L1 regulates the acetylation status and activity of mitochondrial fuel substrate metabolism enzymes. However, the role of GCN5L1 in response to chronic hemodynamic stress is largely unknown. Here, we show that cardiomyocyte-specific GCN5L1 knockout mice (cGCN5L1 KO) display exacerbated heart failure progress ...[more]
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