Ontology highlight
ABSTRACT:
SUBMITTER: Mulligan CM
PROVIDER: S-EPMC3353802 | biostudies-other | 2012 Jun
REPOSITORIES: biostudies-other
Mulligan Christopher M CM Sparagna Genevieve C GC Le Catherine H CH De Mooy Anthony B AB Routh Melissa A MA Holmes Michael G MG Hickson-Bick Diane L DL Zarini Simona S Murphy Robert C RC Xu Fred Y FY Hatch Grant M GM McCune Sylvia A SA Moore Russell L RL Chicco Adam J AJ
Cardiovascular research 20120312 3
<h4>Aims</h4>Cardiolipin (CL) is a tetra-acyl phospholipid that provides structural and functional support to several proteins in the inner mitochondrial membrane. The majority of CL in the healthy mammalian heart contains four linoleic acid acyl chains (L(4)CL). A selective loss of L(4)CL is associated with mitochondrial dysfunction and heart failure in humans and animal models. We examined whether supplementing the diet with linoleic acid would preserve cardiac L(4)CL and attenuate mitochondri ...[more]