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Interleukin-33: Friend or Foe in Gastrointestinal Tract Cancers?

ABSTRACT: Accumulating evidence suggests that Interleukin-33 (IL-33), a member of the IL-1 family, has crucial roles in tissue homeostasis and repair, type 2 immunity, inflammation, and viral infection. IL-33 is a novel contributing factor in tumorigenesis and plays a critical role in regulating angiogenesis and cancer progression in a variety of human cancers. The partially unraveled role of IL-33/ST2 signaling in gastrointestinal tract cancers is being investigated through the analysis of patients' samples and by studies in murine and rat models. In this review, we discuss the basic biology and mechanisms of release of the IL-33 protein and its involvement in gastrointestinal cancer onset and progression.

SUBMITTER: Pisani LF

PROVIDER: S-EPMC10252908 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature

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Interleukin-33: Friend or Foe in Gastrointestinal Tract Cancers?

Pisani Laura Francesca LF Teani Isabella I Vecchi Maurizio M Pastorelli Luca L

Cells 20230526 11

Accumulating evidence suggests that Interleukin-33 (IL-33), a member of the IL-1 family, has crucial roles in tissue homeostasis and repair, type 2 immunity, inflammation, and viral infection. IL-33 is a novel contributing factor in tumorigenesis and plays a critical role in regulating angiogenesis and cancer progression in a variety of human cancers. The partially unraveled role of IL-33/ST2 signaling in gastrointestinal tract cancers is being investigated through the analysis of patients' samp ...[more]

PMID: 37296602

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