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DNAmFitAge: biological age indicator incorporating physical fitness.

ABSTRACT: Physical fitness is a well-known correlate of health and the aging process and DNA methylation (DNAm) data can capture aging via epigenetic clocks. However, current epigenetic clocks did not yet use measures of mobility, strength, lung, or endurance fitness in their construction. We develop blood-based DNAm biomarkers for fitness parameters gait speed (walking speed), maximum handgrip strength, forced expiratory volume in one second (FEV1), and maximal oxygen uptake (VO2max) which have modest correlation with fitness parameters in five large-scale validation datasets (average r between 0.16-0.48). We then use these DNAm fitness parameter biomarkers with DNAmGrimAge, a DNAm mortality risk estimate, to construct DNAmFitAge, a new biological age indicator that incorporates physical fitness. DNAmFitAge is associated with low-intermediate physical activity levels across validation datasets (p = 6.4E-13), and younger/fitter DNAmFitAge corresponds to stronger DNAm fitness parameters in both males and females. DNAmFitAge is lower (p = 0.046) and DNAmVO2max is higher (p = 0.023) in male body builders compared to controls. Physically fit people have a younger DNAmFitAge and experience better age-related outcomes: lower mortality risk (p = 7.2E-51), coronary heart disease risk (p = 2.6E-8), and increased disease-free status (p = 1.1E-7). These new DNAm biomarkers provide researchers a new method to incorporate physical fitness into epigenetic clocks.

SUBMITTER: McGreevy KM

PROVIDER: S-EPMC10258016 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature

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DNAmFitAge: biological age indicator incorporating physical fitness.

McGreevy Kristen M KM Radak Zsolt Z Torma Ferenc F Jokai Matyas M Lu Ake T AT Belsky Daniel W DW Binder Alexandra A Marioni Riccardo E RE Ferrucci Luigi L Pośpiech Ewelina E Branicki Wojciech W Ossowski Andrzej A Sitek Aneta A Spólnicka Magdalena M Raffield Laura M LM Reiner Alex P AP Cox Simon S Kobor Michael M Corcoran David L DL Horvath Steve S

Aging 20230222 10

Physical fitness is a well-known correlate of health and the aging process and DNA methylation (DNAm) data can capture aging via epigenetic clocks. However, current epigenetic clocks did not yet use measures of mobility, strength, lung, or endurance fitness in their construction. We develop blood-based DNAm biomarkers for fitness parameters gait speed (walking speed), maximum handgrip strength, forced expiratory volume in one second (FEV1), and maximal oxygen uptake (VO2max) which have modest co ...[more]

PMID: 36812475

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DNAmFitAge: biological age indicator incorporating physical fitness.

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DNAmFitAge: biological age indicator incorporating physical fitness.

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