Age-associated change in pyruvate metabolism investigated with hyperpolarized ¹³ C-MRI of the human brain.

ABSTRACT: In this study, hyperpolarized ¹³ C MRI (HP-¹³ C MRI) was used to investigate changes in the uptake and metabolism of pyruvate with age. Hyperpolarized ¹³ C-pyruvate was administered to healthy aging individuals (N = 35, ages 21-77) and whole-brain spatial distributions of ¹³ C-lactate and ¹³ C-bicarbonate production were measured. Linear mixed-effects regressions were performed to compute the regional percentage change per decade, showing a significant reduction in both normalized ¹³ C-lactate and normalized ¹³ C-bicarbonate production with age: -7%±2% per decade for ¹³ C-lactate and -9%±4% per decade for ¹³ C-bicarbonate. Certain regions, such as the right medial precentral gyrus, showed greater rates of change while the left caudate nucleus had a flat ¹³ C-lactate versus age and a slightly increasing ¹³ C-bicarbonate versus age. The results show that both the production of lactate (visible as ¹³ C-lactate signal) as well as the consumption of monocarboxylates to make acetyl-CoA (visible as ¹³ C-bicarbonate signal) decrease with age and that the rate of change varies by brain region.

SUBMITTER: Uthayakumar B 

PROVIDER: S-EPMC10258534 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature