Dataset Information

Pharmacokinetics of intranasal amiloride in healthy volunteers.

ABSTRACT: Anxiety and panic disorders are the most common mental illnesses in the United States and lack effective treatment options. Acid-sending ion channels (ASICs) in the brain were shown to be associated with fear conditioning and anxiety responses and therefore are potential targets for treating panic disorder. Amiloride is an inhibitor of the ASICs in the brain and was shown to reduce panic symptoms in preclinical animal models. An intranasal formulation of amiloride will be highly beneficial to treat acute panic attacks due to advantages such as the rapid onset of action and patient compliance. The aim of this single-center, open-label trial was to evaluate the basic pharmacokinetics (PKs) and safety of amiloride after intranasal administration in healthy human volunteers at three doses (0.2, 0.4, and 0.6 mg). Amiloride was detected in plasma within 10 min of intranasal administration and showed a biphasic PK profile with an initial peak within 10 min of administration followed by a second peak between 4 and 8 h of administration. The biphasic PKs indicate an initial rapid absorption via the nasal pathway and later slower absorption by non-nasal pathways. Intranasal amiloride exhibited a dose-proportional increase in the area under the curve and did not exhibit any systemic toxicity. These data indicate that intranasal amiloride is rapidly absorbed and safe at the doses evaluated and can be further considered for clinical development as a portable, rapid, noninvasive, and nonaddictive anxiolytic agent to treat acute panic attacks.

SUBMITTER: Yellepeddi VK

PROVIDER: S-EPMC10264945 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature

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Pharmacokinetics of intranasal amiloride in healthy volunteers.

Yellepeddi Venkata K VK Battaglia Marco M Davies Simon J C SJC Alt Jeremiah J Ashby Shaelene S Shipman Paige P Anderson David J DJ Rower Joseph E JE Reilly Christopher C Voight Michael M Mim Sabiha Rahman SR

Clinical and translational science 20230327 6

Anxiety and panic disorders are the most common mental illnesses in the United States and lack effective treatment options. Acid-sending ion channels (ASICs) in the brain were shown to be associated with fear conditioning and anxiety responses and therefore are potential targets for treating panic disorder. Amiloride is an inhibitor of the ASICs in the brain and was shown to reduce panic symptoms in preclinical animal models. An intranasal formulation of amiloride will be highly beneficial to tr ...[more]

PMID: 36932683

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Dataset Information

Pharmacokinetics of intranasal amiloride in healthy volunteers.

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Pharmacokinetics of intranasal amiloride in healthy volunteers.

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