Calcium carbonate does not affect imatinib pharmacokinetics in healthy volunteers.
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ABSTRACT:
SUBMITTER: Tawbi H
PROVIDER: S-EPMC3880632 | biostudies-literature | 2014 Jan
REPOSITORIES: biostudies-literature
Publications
Calcium carbonate does not affect imatinib pharmacokinetics in healthy volunteers.
Tawbi Hussein H Christner Susan M SM Lin Yan Y Johnson Matthew M Mowrey Emily T ET Cherrin Craig C Chu Edward E Lee James J JJ Puhalla Shannon S Stoller Ronald R Appleman Leonard R LR Miller Brian M BM Beumer Jan H JH
Cancer chemotherapy and pharmacology 20131030 1
<h4>Purpose</h4>Imatinib mesylate (Gleevec(®)/Glivec(®)) has revolutionized the treatment of chronic myeloid leukemias and gastrointestinal stromal tumors, and there is evidence for an exposure response relationship. Calcium carbonate is increasingly used as a calcium supplement and in the setting of gastric upset associated with imatinib therapy. Calcium carbonate could conceivably elevate gastric pH and complex imatinib, thereby influencing imatinib absorption and exposure. We aimed to evaluat ...[more]
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