Ontology highlight
ABSTRACT:
SUBMITTER: Zdorevskyi O
PROVIDER: S-EPMC10266447 | biostudies-literature | 2023 Jun
REPOSITORIES: biostudies-literature
Zdorevskyi Oleksii O Djurabekova Amina A Lasham Jonathan J Sharma Vivek V
Chemical science 20230510 23
Respiratory complex I is a redox-driven proton pump contributing to about 40% of total proton motive force required for mitochondrial ATP generation. Recent high-resolution cryo-EM structural data revealed the positions of several water molecules in the membrane domain of the large enzyme complex. However, it remains unclear how protons flow in the membrane-bound antiporter-like subunits of complex I. Here, we performed multiscale computer simulations on high-resolution structural data to model ...[more]