Dataset Information

Inflammatory potential of diet and risk of mortality in normal-weight adults with central obesity.

ABSTRACT:

Background & aims

Inflammatory potential of diet may contribute to poor health outcomes in individuals with metabolic disorders. In a representative sample of the U.S. population, we investigated the association between consuming a pro-inflammatory diet and mortality risk in adults with normal range of body mass index (BMI) but with central obesity.

Methods

This prospective cohort study included 3521 adults 20-90 years of age with normal BMI who participated in the National Health and Nutrition Examination Survey III, 1988-1994 and did not have a history of cardiovascular disease (CVD) or cancer and did not change their dietary intake in the year preceding baseline measurements. Mortality from all causes, CVD, and cancer was ascertained from the National Death Index. Normal-weight central obesity (NWCO, n = 1777) was defined as those with BMI 18.5 to <25 kg/m² and waist-to-hip ratio (WHR) ≥0.85 in women and ≥0.90 in men. Severe central obesity was defined as WHR ≥0.92 in women and ≥1.00 in men. The dietary inflammatory index (DII®) was computed based on baseline dietary intake using 24-h dietary recalls, and associations with mortality were estimated using multivariable Cox proportional hazards regression.

Results

In individuals with NWCO, DII score (i.e., more pro-inflammatory diet) was associated with increased risk of CVD mortality (HR_{T3 vs T1}, 1.89 [95% CI, 1.01-3.53], P trend = 0.04; HR _{1 SD increase} 1.29 [95% CI, 1.06-1.57]). This association was stronger with more severe central obesity (HR_{T3 vs T1}, 2.79 [95% CI, 1.10-7.03], P trend = 0.03; HR _{1 SD increase} 1.52 [95% CI, 1.05-2.21]). DII score was not associated with increased risk of mortality in normal-weight individuals without central obesity or with risk of cancer mortality in either group.

Conclusion

Among individuals in the normal-weight range of BMI, a pro-inflammatory diet assessed by high DII scores was associated with increased risk of CVD mortality in those with central obesity.

SUBMITTER: Choi MK

PROVIDER: S-EPMC10284332 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Inflammatory potential of diet and risk of mortality in normal-weight adults with central obesity.

Choi Moon Kyung MK Park Yong-Moon Mark YM Shivappa Nitin N Hong Oak-Kee OK Han Kyungdo K Steck Susan E SE Hebert James R JR Merchant Anwar T AT Sandler Dale P DP Lee Seong-Su SS

Clinical nutrition (Edinburgh, Scotland) 20221215 2

<h4>Background & aims</h4>Inflammatory potential of diet may contribute to poor health outcomes in individuals with metabolic disorders. In a representative sample of the U.S. population, we investigated the association between consuming a pro-inflammatory diet and mortality risk in adults with normal range of body mass index (BMI) but with central obesity.<h4>Methods</h4>This prospective cohort study included 3521 adults 20-90 years of age with normal BMI who participated in the National Health ...[more]

PMID: 36603461

Similar Datasets

Project description:ImportanceCurrent public health guidelines for obesity prevention and control focus on promoting a normal body mass index (BMI), rarely addressing central obesity, which is reflected by high waist circumference (WC) and common in the general population. Studies of the association of normal-weight central obesity with long-term health outcomes are sparse.ObjectiveTo examine associations of normal-weight central obesity with all-cause and cause-specific mortality in postmenopausal women in the United States.Design, setting, and participantsA nationwide prospective cohort study of 156 624 postmenopausal women enrolled in the Women's Health Initiative at 40 clinical centers in the United States between 1993 and 1998. These women were observed through February 2017. Data analysis was performed from September 15, 2017, to March 13, 2019.ExposuresDifferent combinations of BMI (calculated as weight in kilograms divided by height in meters squared; normal weight: BMI, 18.5-24.9; overweight: BMI, 25.0-29.9; and obesity: BMI, ≥30) and WC (normal: WC, ≤88 cm and high: WC, >88 cm).Main outcomes and measuresMortality from all causes, cardiovascular disease, and cancer.ResultsOf the 156 624 women (mean [SD] age, 63.2 [7.2] years), during 2 811 187 person-years of follow-up, 43 838 deaths occurred, including 12 965 deaths from cardiovascular disease (29.6%) and 11 828 deaths from cancer (27.0%). Compared with women with normal weight and no central obesity and adjusted for demographic characteristics, socioeconomic status, lifestyle factors, and hormone use, the hazard ratio for all-cause mortality was 1.31 (95% CI, 1.20-1.42) among women with normal weight and central obesity, 0.91 (95% CI, 0.89-0.94) among women with overweight and no central obesity, 1.16 (95% CI, 1.13-1.20) for women with overweight and central obesity, 0.93 (95% CI, 0.89-0.94) for women with obesity and no central obesity, and 1.30 (95% CI, 1.27-1.34) for women with obesity and central obesity. Compared with normal weight without central obesity, normal-weight central obesity was associated with higher risk of cardiovascular disease mortality (hazard ratio, 1.25; 95% CI, 1.05-1.46) and cancer mortality (hazard ratio, 1.20; 95% CI, 1.01-1.43).Conclusions and relevanceNormal-weight central obesity in women was associated with excess risk of mortality, similar to that of women with BMI-defined obesity with central obesity. These findings underscore the need for future public health guidelines to include the prevention and control of central obesity, even in individuals with normal BMI.

Dataset Information

Inflammatory potential of diet and risk of mortality in normal-weight adults with central obesity.

Background & aims

Methods

Results

Conclusion

Publications

Inflammatory potential of diet and risk of mortality in normal-weight adults with central obesity.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets