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Cost-effectiveness of overactive bladder treatments from a US commercial and payer perspective.

ABSTRACT: Aim: The cost-effectiveness of treatment options (anticholinergics, β3-adrenoceptor agonists, onabotulinumtoxinA, sacral nerve stimulation and percutaneous tibial stimulation [the latter two including new rechargeable neurostimulators]) for the management of overactive bladder (OAB) were compared with best supportive care (BSC) using a previously published Markov model. Materials & methods: Cost-effectiveness was evaluated over a 15-year time horizon, and sensitivity analyses were performed using 2- and 5-year horizons. Discontinuation rates, resource utilization, and costs were derived from published sources. Results: Using Medicare and commercial costs over a 15-year time period, onabotulinumtoxinA 100U had incremental cost-effectiveness ratios (ICERs) gained of $39,591/quality-adjusted life-year (QALY) and $42,255/QALY, respectively, versus BSC, which were the lowest ICERs of all assessed treatments. The sensitivity analyses at 2- and 5-year horizons also showed onabotulinumtoxinA to be the most cost-effective of all assessed treatments versus BSC. Conclusion: OnabotulinumtoxinA 100U is currently the most cost-effective treatment for OAB.

SUBMITTER: Murray B

PROVIDER: S-EPMC10288955 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature

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Cost-effectiveness of overactive bladder treatments from a US commercial and payer perspective.

Murray Brian B Miles-Thomas Jennifer J Park Amy J AJ Nguyen Victor B VB Tung Amy A Gillard Patrick P Lalla Anjana A Nitti Victor W VW Chermansky Christopher J CJ

Journal of comparative effectiveness research 20230119 2

<b>Aim:</b> The cost-effectiveness of treatment options (anticholinergics, β3-adrenoceptor agonists, onabotulinumtoxinA, sacral nerve stimulation and percutaneous tibial stimulation [the latter two including new rechargeable neurostimulators]) for the management of overactive bladder (OAB) were compared with best supportive care (BSC) using a previously published Markov model. <b>Materials & methods:</b> Cost-effectiveness was evaluated over a 15-year time horizon, and sensitivity analyses were ...[more]

PMID: 36655745

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Cost-effectiveness of overactive bladder treatments from a US commercial and payer perspective.

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Cost-effectiveness of overactive bladder treatments from a US commercial and payer perspective.

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