Ontology highlight
ABSTRACT:
SUBMITTER: Weiss JM
PROVIDER: S-EPMC10290955 | biostudies-literature | 2023 Jun
REPOSITORIES: biostudies-literature
Weiss Jonathan M JM Palmieri Erika M EM Gonzalez-Cotto Marieli M Bettencourt Ian A IA Megill Emily L EL Snyder Nathaniel W NW McVicar Daniel W DW
Nature metabolism 20230612 6
Itaconate, the product of the decarboxylation of cis-aconitate, regulates numerous biological processes. We and others have revealed itaconate as a regulator of fatty acid β-oxidation, generation of mitochondrial reactive oxygen species and the metabolic interplay between resident macrophages and tumors. In the present study, we show that itaconic acid is upregulated in human non-alcoholic steatohepatitis and a mouse model of non-alcoholic fatty liver disease. Male mice deficient in the gene res ...[more]