Mechanistic Insights into the Antibiofilm Mode of Action of Ellagic Acid.
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ABSTRACT:
SUBMITTER: Ratti A
PROVIDER: S-EPMC10302398 | biostudies-literature | 2023 Jun
REPOSITORIES: biostudies-literature
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Mechanistic Insights into the Antibiofilm Mode of Action of Ellagic Acid.
Ratti Alessandro A Fassi Enrico M A EMA Forlani Fabio F Mori Matteo M Villa Federica F Cappitelli Francesca F Sgrignani Jacopo J Roda Gabriella G Cavalli Andrea A Villa Stefania S Grazioso Giovanni G
Pharmaceutics 20230617 6
Bacterial biofilm is a major contributor to the persistence of infection and the limited efficacy of antibiotics. Antibiofilm molecules that interfere with the biofilm lifestyle offer a valuable tool in fighting bacterial pathogens. Ellagic acid (EA) is a natural polyphenol that has shown attractive antibiofilm properties. However, its precise antibiofilm mode of action remains unknown. Experimental evidence links the NADH:quinone oxidoreductase enzyme WrbA to biofilm formation, stress response, ...[more]
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