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Mechanistic action of weak acid drugs on biofilms.

ABSTRACT: Selective permeability of a biofilm matrix to some drugs has resulted in the development of drug tolerant bacteria. Here we studied the efficacy of a weak organic acid drug, N-acetyl-L-cysteine (NAC), on the eradication of biofilms formed by the mucoid strain of Pseudomonas aeruginosa and investigated the commonality of this drug with that of acetic acid. We showed that NAC and acetic acid at pH?

SUBMITTER: Kundukad B

PROVIDER: S-EPMC5500524 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature

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Mechanistic action of weak acid drugs on biofilms.

Kundukad Binu B Schussman Megan M Yang Kaiyuan K Seviour Thomas T Yang Liang L Rice Scott A SA Kjelleberg Staffan S Doyle Patrick S PS

Scientific reports 20170706 1

Selective permeability of a biofilm matrix to some drugs has resulted in the development of drug tolerant bacteria. Here we studied the efficacy of a weak organic acid drug, N-acetyl-L-cysteine (NAC), on the eradication of biofilms formed by the mucoid strain of Pseudomonas aeruginosa and investigated the commonality of this drug with that of acetic acid. We showed that NAC and acetic acid at pH < pKa can penetrate the matrix and eventually kill 100% of the bacteria embedded in the biofilm. Once ...[more]

PMID: 28684849

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