Dataset Information

Detection of Relative Afferent Pupillary Defects Using Eye Tracking and a VR Headset.

ABSTRACT:

Purpose

The purpose of this study was to assess the feasibility of detecting relative afferent pupillary defects (RAPDs) using a commercial virtual reality headset equipped with an eye tracker.

Methods

This is a cross-sectional study in which we compare the new computerized RAPD test with the traditional clinical standard using the swinging flashlight test. Eighty-two participants including 20 healthy volunteers aged 10 to 88 years were enrolled in this study. We present a bright/dark stimulus alternating between the eyes every 3 seconds using a virtual reality headset, and we simultaneously record changes in pupil size. To determine the presence of an RAPD, we developed an algorithm analyzing the pupil size differences. For the assessment of the performance of the automated and the manual measurement a post hoc impression based on all available data is created. The accuracy of the manual clinical evaluation and the computerized method is compared using confusion matrices and the gold standard of the post hoc impression. The latter is based on all available clinical information.

Results

We found that the computerized method detected RAPD with a sensitivity of 90.2% and an accuracy of 84.4%, as compared to the post hoc impression. This was not significantly different from the clinical evaluation with a sensitivity of 89.1% and an accuracy of 88.3%.

Conclusions

The presented method offers an accurate, easy to use, and fast method to measure an RAPD. In contrast to today's clinical practice, the measures are quantitative and objective.

Translational relevance

Computerized testing of Relative Afferent Pupillary Defects (RAPD) using a VR-headset and eye-tracking reaches non-inferior performance compared with senior neuro-ophthalmologists.

SUBMITTER: Bruegger D

PROVIDER: S-EPMC10309159 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Detection of Relative Afferent Pupillary Defects Using Eye Tracking and a VR Headset.

Bruegger Dominik D Grabe Hilary M HM Vicini Rino R Dysli Muriel M Lussi David D Abegg Mathias M

Translational vision science & technology 20230601 6

<h4>Purpose</h4>The purpose of this study was to assess the feasibility of detecting relative afferent pupillary defects (RAPDs) using a commercial virtual reality headset equipped with an eye tracker.<h4>Methods</h4>This is a cross-sectional study in which we compare the new computerized RAPD test with the traditional clinical standard using the swinging flashlight test. Eighty-two participants including 20 healthy volunteers aged 10 to 88 years were enrolled in this study. We present a bright/ ...[more]

PMID: 37367721

Similar Datasets

Project description:Exposure is key to message effects. No effects can ensue if a health, political, or commercial message is not noticed. Yet, existing research in communication, advertising, and related disciplines often measures 'opportunities for exposure' at an aggregate level, whereas knowing whether recipients were 'actually exposed' to a message requires a micro-level approach. Micro-level research, on the other hand, focuses on message processing and retention, takes place under highly controlled laboratory conditions with forced message exposure, and largely ignores how recipients attend selectively to messages under more natural conditions. Eye-tracking enables us to assess actual exposure, but its previous applications were restricted to screen-based reading paradigms lacking ecological validity or field studies that suffer from limited experimental control. Our solution is to measure eye-tracking within an immersive VR environment that creates the message delivery and reception context. Specifically, we simulate a car ride down a highway alongside which billboards are placed. The VR headset (HP Omnicept Pro) provides an interactive 3D view of the environment and holds a seamlessly integrated binocular eye tracker that records the drivers' gaze and detects all fixations on the billboards. This allows us to quantify the nexus between exposure and reception rigorously, and to link our measures to subsequent memory, i.e., whether messages were remembered, forgotten, or not even encoded. An empirical study shows that incidental memory for messages differs based on participants' gaze behavior while passing the billboards. The study further shows how an experimental manipulation of attentional demands directly impacts drivers' gaze behavior and memory. We discuss the large potential of this paradigm to quantify exposure and message reception in realistic communication environments and the equally promising applications in new media contexts (e.g., the Metaverse).

Project description:Recent years have witnessed much research on semantic analysis and syntactic anatomy in ordinary language processing. However, it is still a matter of considerable debate about when and how the semantic integration of single word meanings works and interacts with syntax during on-line comprehension. This study, in an eye-tracking paradigm, took 38 native speakers of Mandarin Chinese as the participants and took Chinese relative clauses as stimuli to figure out the functions of semantics by investigating the conditioning semantic factors influencing and governing the word order variation of Chinese relative clauses during different processing stages. Accordingly, this study manipulated two syntactic variables, i.e., relative clause type and the position of the numeral-classifier sequence (NCL) in the relative clause, as well as a semantic variable, i.e., the abstractness of the head noun that the relative clause modified. Specifically, the study addressed two questions: (1) when semantics is activated and interacts with syntax and (2) how semantics affects syntax during the time course of Chinese relative clause processing. The results indicated that: (1) Semantics was activated and interacted with syntax during the early and late processing stages of Chinese relative clauses, which challenged the sequential order of syntactic and semantic processes, and supported the claims of the Concurrent Processing Model. (2) The syntactic order of the Chinese relative clause was affected by the semantic information of the head noun that the clause modified. Object-extraction relative clauses (ORCs) had a conjunction preference for the order "an object relative clause preceding the numeral-classifier sequence and the head noun." Instead, the subject-extraction relative clause (SRC) which modified a concrete noun (CN) had a co-occurrence preference for the order "numeral-classifier sequence preceding the subject relative clause and the head noun," while the subject-extraction relative clause which modified an abstract noun (AN) had a co-occurrence preference for the order "subject relative clause preceding the numeral-classifier sequence and the head noun." The findings of this study were evaluated in light of the perspectives of truth value semantics of the syntactic components, the semantic compatibility of numeral-classifier sequence and its modified noun as well as the discourse functions of outer modifier nominals and inner modifier nominals.

Dataset Information

Detection of Relative Afferent Pupillary Defects Using Eye Tracking and a VR Headset.

Purpose

Methods

Results

Conclusions

Translational relevance

Publications

Detection of Relative Afferent Pupillary Defects Using Eye Tracking and a VR Headset.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets